Gut–brain Axis: Impact of Intestinal Inflammation and Micronutrient Deficiency on Psychomotor Development and Cognitive Functions in Egyptian Children with UndernutritionGut–brain Axis: Impact of Intestinal Inflammation and Micronutrient Deficiency on Psychomotor Development and Cognitive Functions in Egyptian Children with Undernutrition

Cognitive impairment, growth faltering and stunting are pervasive in many countries. mostly causes unknown. Role of intestinal inflammation such cases should be minded especially low- middle-income We assessed serum markers inflammation, fecal micronutrients with aged 1 to 10 years who suffer from moderate or severe malnutrition “weight-for-age z-score height-for-age z- Score (WAZ HAZ) less than -2 SD”. abilities were using Wechsler intelligence scale for preschool school children, Bayley III. 55.6% below average had mild retardation while 24.5% 5% children 2 regarding cognitive functions. Cases showed statistically significant reduction vitamin D, zinc iron as compared control. Serum (alpha 1- glycoprotein (a1-AGP), endotoxin core protein (EndoCAB)) antitrypsin (AAT) neopterin (NEOP)) higher controls. School negative correlation between processing functions and( a1-AGP), positive perceptual reasoning A. Children years, correlations motor function (AAT), tumor necrosis factor- alpha (TNF-a) (EndoCAB), language zinc. In conclusion, our study impaired neurocognitive psychomotor malnourished stunted children. Also, vitamins minerals deficiency increased observed healthy